GHK-Cu
Widely used in skincare. Topical evidence for skin firmness and repair is modest but real.
GHK-Cu occurs naturally in blood plasma, and levels decline with age. It was identified in the 1970s and is now a common ingredient in serums and creams.
What the research shows
- Small studies of topical use report improvements in skin density, fine lines and wound healing.
- Evidence for injected GHK-Cu in humans is lacking.
- As a cosmetic ingredient it is widely available and generally well tolerated.
Doses used in research
No human dose has been established. This compound hasn't been through published human dosing trials, so any dose you see online comes from anecdote, not research.
Key sources
- Pickart & Margolina, Int J Mol Sci 2018
Last reviewed: November 2026
This page reports what published research and official labels describe. It isn't a recommendation to use any compound. Decisions about any compound should be made with a licensed clinician.